Insulin resistance and cardiovascular risk factors in childhood metabolic dysfunction-associated steatotic liver disease

Purpose: The objectives of the present study were to develop biochemical indices as a more practical way for early diagnosis cases with suspected metabolic dysfunction-assosiated steatotic liver disease (MASLD) and easy biomarkers enable clinicians recognize MASLD in obese children. 
 Materials Methods: A total 90 patients who had 70 healthy volunteering children between ages 6-18 diagnosed reference ESPGHAN 2012 Guideline January 2020 March 2023 included. Age, gender, Anthropometric measurements analysis determined. Some Biochemical ratios such HOMA-IR, HOMA-β, FGIR, QUICKI, AIP etc calculated.
 Results: There 40 (44.4%) girls 50 (55.6%) boys patient group.A positive correlation was found AST, GGT, TSH, LDL, TG, cholesterol, HDL, FAS, insulin, QUICKI score, MHR, LHR, LKR, THR ALT/AST Systemic Immun Inflammatory Index values analysis. ROC results HOMA-IR value taken 2.94, specificity diagnostic be 52.20% sensitivity 80.0%.
 Conclusion: has an increasing trend today.Based on design study, it concluded that almost all parameters obtained are among most accurate useful determine IR predict complications.